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What 19 owners told NHTSA about the 2021 Mercedes-benz E-class Wagon

These are the actual owner complaints behind this car’s reliability verdict, filed with the federal government, unedited. They’re unverified reports, not confirmed defects: read them as leads for your pre-purchase inspection, not a diagnosis.

All (19)Crash / fire / injury (1)Electrical system (7)Engine (6)Backup camera & sensors (3)Fuel system (3)Transmission & drivetrain (2)Brakes (1)Wheels (1)

2 of 19 complaints match · Transmission & drivetrain · clear filters

Jan 4, 2026Transmission & drivetrain

With the car only have about 15,000 miles the transmission has failed . I have seen there have been recalls of other models with similar complaints of transmission failure .

NHTSA ODI 11708688

Jul 10, 2025Transmission & drivetrain

The Mercedes E350, with 22,000 miles suffered a catastrophic transmission failure while driving on the highway. I managed to exit the highway but the car could not be moved and left me stranded.

NHTSA ODI 11672435

Working with the data? Download all 19 complaints as CSV · fetched from NHTSA July 19, 2026

How to use these: a complaint is one owner’s report, filed voluntarily and published unverified. Patterns matter more than any single story. If several owners describe the same failure at similar mileage, put that system at the top of your pre-purchase inspection list. Back to the full 2021 Mercedes-benz E-class Wagon verdict →