Home · 2021 GMC Sierra 2500 Hd · Complaints

What 49 owners told NHTSA about the 2021 GMC Sierra 2500 Hd

These are the actual owner complaints behind this car’s reliability verdict, filed with the federal government, unedited. They’re unverified reports, not confirmed defects: read them as leads for your pre-purchase inspection, not a diagnosis.

All (49)Crash / fire / injury (4)Transmission & drivetrain (12)Lights (9)Engine (8)Electrical system (6)Body & structure (5)Brakes (5)Latches & locks (4)Driver assistance (3)Airbags (2)Backup camera & sensors (1)

8 of 49 complaints match · Engine · clear filters

Jun 26, 2026Transmission & drivetrainEngineFuel system

I am reporting repeated failures involving both the transmission and diesel emissions (DEF) system on my 2021 GMC Sierra 2500HD Denali equipped with the 6.6L Duramax diesel engine and Allison 10-speed automatic transmission. While under warranty, the truck required replacement of the aftertreatment fuel injector and later the Reductant Control Module due to DEF/emissions system failures. General Motors also completed recall-related transmission software updates on the vehicle. At approximately 154,833 miles, the transmission began shifting improperly, set transmission fault codes, and required complete replacement at my expense. Less than 5,000 miles later, the vehicle again experienced a "Service DEF System" warning with multiple diagnostic trouble codes. Repairs required replacement of the DEF tank, DEF heater assembly, and NOx sensor. These repeated failures involve major drivetrain and emissions components on a heavy-duty truck. DEF system failures can place the vehicle into reduced-power (derate) mode, limiting vehicle performance and creating potential safety concerns while driving or towing. I am submitting this complaint so these failures can be documented as part of NHTSA's evaluation of similar vehicles.

NHTSA ODI 11746749

Apr 1, 2026Engine

The contact owns a 2021 GMC Sierra 2500. The contact stated that while driving at 55 MPH, the vehicle stalled unexpectedly. There were no warning lights illuminated. The vehicle was taken to the local dealer, where it was diagnosed, and determined that the engine needed to be replaced. The engine was replaced; however, the failure recurred. While at a stop and attempting to drive around a curve, the vehicle stalled. No warning lights were illuminated. The vehicle was taken to the local dealer, where it was diagnosed with engine failure. The vehicle was not repaired. The failure mileage was approximately 77,000. The VIN was not available.

NHTSA ODI 11728457

Feb 3, 2026Engine

80,000 Miles, complete engine break down. 12,000 to repair

NHTSA ODI 11715295

Dec 19, 2024Transmission & drivetrainEngine

The contact owns a 2021 GMC Sierra 2500. The contact stated while driving 40-55 MPH, the vehicle started losing motive power. The contact stated while pulling into a nearby independent mechanic shop, the vehicle started jerking significantly and stalled midway. The check engine warning light was illuminated. The mechanic diagnosed the vehicle with transmission failure. The vehicle was towed to the residence. The local dealer and several unknown dealers were notified of the failure and informed the contact that the transmission assembly was not available and could not be ordered. The vehicle was towed to CJ's Transmission, where the transmission was taken apart. The mechanic determined that the transmission needed to be replaced. The vehicle was being repaired with a rebuilt transmission. The contact received notification of NHTSA Campaign Number: 24V797000 (Power Train); however, the part to do the recall repair was not yet available. The local dealer was contacted. The contact stated that the manufacturer had exceeded a reasonable amount of time for the recall repair. The manufacturer was made aware of the failure and offered a modest monetary compensation for the repair. The failure mileage was approximately 134,000. Parts distribution disconnect.

NHTSA ODI 11631610

Aug 15, 2024Electrical systemEngineDriver assistance

Smog system check and Engan warning light keeps come on.

NHTSA ODI 11608733

Feb 28, 2024Engine

The contact owns a 2021 GMC Sierra 2500. The contact stated that the vehicle was equipped with an engine block heater that he plugged into the vehicle when the weather was below 32 degrees to start the vehicle. The contact stated that he noticed that the engine block heater was causing the GFCI outlet in his residence, to experience an electrical short circuit. The dealer was notified of the failure and informed the contact that it was a known failure. An appointment was scheduled for diagnostic testing. The vehicle was not diagnosed or repaired. The contact related the failure to NHTSA Campaign Number: 19V328000 (Engine) however, the VIN was not included. The manufacturer was notified of the failure and a case was opened. The failure mileage was approximately 55,000.

NHTSA ODI 11574476

May 16, 2022Engine

Diesel Exhaust Fluid tank, high pressure

NHTSA ODI 11464852

Feb 28, 2021EngineBackup camera & sensorsDriver assistance

THE TRUCK IS PARKED AT DEALERSHIP

NHTSA ODI 11398288

Working with the data? Download all 49 complaints as CSV · fetched from NHTSA July 19, 2026

How to use these: a complaint is one owner’s report, filed voluntarily and published unverified. Patterns matter more than any single story. If several owners describe the same failure at similar mileage, put that system at the top of your pre-purchase inspection list. Back to the full 2021 GMC Sierra 2500 Hd verdict →